Inter hope Mauro Icardi and Marcelo Brozovic can get the better of SPAL and end their six-round winless streak, while Rafinha is on the bench.
It kicks off at 11.30 GMT, follow the build-up and action from all eight of today’s Serie A games on the LIVEBLOG.
The Nerazzurri were Scudetto contenders up until mid-December, but their season has gone off the rails with no victories in the last six rounds.
They also crashed out of the Coppa Italia to rivals Milan during that period, so securing a top four finish is the only thing Luciano Spalletti must focus on.
Lazio have now gone three points clear in third place after winning their game in hand against Udinese and Inter must give a response.
As for SPAL, they are in Serie A for the first time since 1968 and go into this weekend two points off the safety zone.
There were positive draws against Torino and Udinese, but they’re without a victory since squeezing past Benevento on December 17.
Marco Borriello, Eros Schiavon and Pa Konate are out injured, so Mirko Antenucci leads the attack with pacey Pasquale Schiattarella.
January signing Jasmin Kurtic is in the starting XI, with Everton Luiz on the bench, but the big news is the return of youngster Alex Meret in goal after a lengthy injury absence.
Inter have no fitness issues to contend with, so Spalletti can field his first choice XI with Ivan Perisic, Brozovic and Antonio Candreva supporting Icardi.
Borja Valero takes a deeper role with Matias Vecino, benching Roberto Gagliardini.
Rafinha completed his transfer this week from Barcelona, on loan with option to buy, and is on the bench along with Lisandro Lopez.
SPAL: Meret; Cionek, Vicari, Felipe; Lazzari, Schiattarella, Viviani, Grassi, Mattiello; Kurtic; Antenucci
SPAL bench: Gomis, Marchegiani, Cremonesi, Bonazzoli, Floccari, Vaisanen, Salamon, Vitale, Guimaraes, Costa, Paloschi, Drame
Inter: Handanovic; Cancelo, Skriniar, Miranda, D’Ambrosio; Vecino, Borja Valero; Candreva, Brozovic, Perisic; Icardi
Inter bench: Padelli, Berni, Lisandro Lopez, Gagliardini, Rafinha, Ranocchia, Karamoh, Santon, Eder, Dalbert, Pinamonti, Nagatomo
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