Milan aim to continue their positive streak and rely on Patrick Cutrone as they visit a SPAL side in crisis, ready to sack Leonardo Semplici.
It kicks off in Ferrara at 14.00 GMT.
The Rossoneri have been revitalised under Gennaro Gattuso, unbeaten in seven competitive games between Serie A and the Coppa Italia.
They were held to a 1-1 draw at Udinese last week after going down to 10 men, as Davide Calabria was sent off and is therefore suspended.
Milan aim to continue their positive streak and rely on Patrick Cutrone as they visit a SPAL side in crisis, ready to sack Leonardo Semplici.
It kicks off in Ferrara at 14.00 GMT.
The Rossoneri have been revitalised under Gennaro Gattuso, unbeaten in seven competitive games between Serie A and the Coppa Italia.
They were held to a 1-1 draw at Udinese last week after going down to 10 men, as Davide Calabria was sent off and is therefore suspended.
Nikola Kalinic, Andrea Conti and Marco Storari are injured, so Patrick Cutrone gets the nod in attack rather than the misfiring Andre Silva, who wasted his opportunity of a rare start in Udine.
Ricardo Rodriguez returns from injury just in time to join Ignazio Abate at full-back.
SPAL, on the other hand, are struggling badly with one win in their last 13 competitive matches.
A good run of back-to-back draws with Udinese and Inter was followed by a desperately disappointing performance in the 2-0 defeat to Cagliari, leaving them in the drop zone and Coach Semplici in the balance.
Francesco Vicari is suspended, with Eros Schiavon, Pa Konate and ex-Milan striker Marco Borriello injured.
January signings Everton Luiz and Jasmin Kurtic get a starting spot at the Stadio Mazza.
Mirco Antenucci has proved the most decisive player in the squad, contributing six goals and five assists in 17 Serie A games this season.
SPAL have never beaten Milan in Serie A on home turf, drawing eight of their 16 meetings. Their lone top flight victory over the Diavolo was 1-0 at San Siro in June 1957.
SPAL: Meret; Simic, Salamon, Felipe; Lazzari, Viviani, Everton Luiz, Grassi, Mattiello; Kurtic, Antenucci
SPAL bench: Gomis, Marchegiani, Väisänen, Costa, Dramé, Konate, Schiattarella, Vitale, Paloschi, Bonazzoli, Floccari
Milan: G Donnarumma; Abate, Bonucci, Romagnoli, Ricardo Rodriguez; Kessie, Biglia, Bonaventura; Suso, Cutrone, Calhanoglu
Milan bench: A Donnarumma, Musacchio, Zapata, Antonelli, Gomez, Locatelli, Montolivo, Mauri, Borini, Andre Silva