Nikola Kalinic, Andrea Conti and suspended Franck Kessie are out of the Milan squad against Sampdoria.
It kicks off on Sunday at 19.45 GMT, click here for a match preview.
Kalinic has still not shaken off his injury that forced him out of the 3-0 Europa League victory over Ludogorets on Thursday.
Conti is a long-term absentee following knee surgery over the summer, while midfielder Kessie will miss his first game of the season due to a ban.
Patrick Cutrone is expected to start in attack rather than Andre Silva.
Milan squad for Sampdoria: A Donnarumma, G Donnarumma, Guarnone; Abate, Antonelli, Bonucci, Calabria, Gomez, Musacchio, Rodriguez, Romagnoli, C Zapata; Biglia, Bonaventura, Calhanoglu, Locatelli, Mauri, Montolivo; Borini, Cutrone, Andre Silva, Suso
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