Inter are forced into several changes with Eder, Yann Karamoh and Andrea Ranocchia starting in a trip to on-form Genoa.
It kicks off at Marassi at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
Luciano Spalletti’s side rediscovered winning ways against nine-man Bologna last week, even if it proved hard going with goals from Eder and Karamoh.
Those two forwards start again tonight, because Mauro Icardi and Ivan Perisic aren’t even in the squad due to muscular injuries.
Antonio Candreva returns to the line-up after he was dropped against Bologna, while Borja Valero moves into a more advanced role.
Joao Miranda is also injured, so Andrea Ranocchia steps into the defence, having celebrated his 30th birthday this week.
Genoa have been transformed since Davide Ballardini took over from Ivan Juric, putting together six wins, three draws and three losses, but the defeats were to Atalanta, Juventus and Udinese.
There is an injury crisis for the Grifone too, missing Adel Taarabt, Giuseppe Rossi, Miguel Veloso, Armando Izzo and Davide Biraschi.
Andrej Galabinov leads the attack with support from ex-Inter players Goran Pandev, Daniel Bessa and Diego Laxalt.
There’s bound to be a passionate atmosphere at the Stadio Luigi Ferraris, known as Marassi, because before kick-off there’s a tribute to Genoese singer-songwriter Fabrizio De Andre with the crowd belting out some of his best-known songs.
Inter have a very poor record in this fixture, losing their last four trips to Genoa.
Genoa: Perin; Rossettini, Spolli, Zukanovic; Rosi, Bessa, Bertolacci, Hiljemark, Laxalt; Pandev, Galabinov
Genoa bench: Lamanna, Zima, Cofie, Lapadula, El Yamiq, Migliore, Lazovic, Rigoni, Pereira, Omeonga, Medeiros
Inter: Handanovic; Cancelo, Ranocchia, Skriniar, D’Ambrosio; Gagliardini, Vecino; Candreva, Borja Valero, Karamoh; Eder
Inter bench: Padelli, Pissardo, Lisandro Lopez, Rafinha, Santon, Dalbert, Emmers, Brozovic, Lombardoni, Pinamonti