Genoa midfielder Daniel Bessa concedes this “isn’t like any other match” for the former Inter youth product.
It kicks off at 19.45 GMT, click here for the line-ups and Liveblog.
“We are on a good period of form and want to cause problems for a big club like Inter,” the midfielder told Mediaset Premium.
“I spent many years in the Inter youth academy, so of course this isn’t like any other match for me. This kind of a fixture gives you something extra."
Bessa started the season at Hellas Verona, but joined Genoa in the January transfer window.
“It’s important to be playing at home and we’ll try to make the most of the atmosphere.”
See the latest Serie A predictions and betting tips with Eurotips.co.uk