Lazio have the opportunity to go into fourth place as they host struggling Hellas Verona, but must replace banned Lucas Leiva.
It kicks off at 19.45 GMT, click here for the match preview.
With Inter’s 2-0 defeat to Genoa and Roma climbing into third, a victory here would put the Aquile in the top four – a Champions League qualifying spot.
They used a heavily-rotated squad in Thursday’s Europa League defeat to Steaua Bucharest, the first leg of the Round of 32.
Lucas Leiva is suspended, but otherwise it’s a full-strength side with Stefan de Vrij, Sergej Milinkovic-Savic, Marco Parolo, Luis Alberto and Ciro Immobile starting.
Jordan Lukaku and Wallace are given a chance ahead of ex-Verona defender Martin Caceres.
Hellas Verona are in a battle to avoid dropping straight back down to Serie B, which has become more open since Benevento beat Crotone 3-2 on Sunday.
Yet they are unpredictable, capable of beating Milan 3-0 and Fiorentina 4-1.
Moise Kean returns from his ban to bolster the attack, but Alessio Cerci and Alex Ferrari haven’t made the trip to Rome.
Romanian defender Deian Boldor, on loan from Bologna and formerly of Montreal Impact, makes his Serie A debut.
Verona have not beaten Lazio in Rome since their Scudetto-winning 1984-85 campaign, managing two draws and eight defeats.
Expect entertainment, because there have been 36 goals in the last eight editions of this fixture between Serie A and the Coppa Italia.
Lazio: Strakosha; Wallace, de Vrij, Radu; Marusic, Milinkovic-Savic, Parolo, Lulic, Lukaku; Luis Alberto; Immobile
Lazio bench: Guerrieri, Vargic, Patric, Basta, Caceres, Bastos, Luiz Felipe, Di Gennaro, Murgia, Felipe Anderson, Nani, Caicedo
Verona: Nicolas; Boldor, Caracciolo, Vukovic, Fares; Romulo, Buchel, Valoti, Matos; Verde, Kean
Verona bench: Silvestri, Coppola, Heurtaux, Bearzotti, Souprayen, Felicioli, Fossati, Aarons, Calvano, Zuculini, Petkovic, Lee
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