Roma rely on Cengiz Under, Edin Dzeko and Alessandro Florenzi in their Champions League trip to giant-killers Shakhtar Donetsk.
The first leg of the Round of 16 kicks off in Kharkiv at 19.45 GMT.
The Giallorossi topped their group ahead of Chelsea and Atletico Madrid, so have played some of their best football of the season in Europe.
Eusebio Di Francesco is without Maxime Gonalons, Rick Karsdorp and January signing Jonathan Silva.
The big question marks were around Florenzi, who was meant to be in yesterday’s Press conference, but pulled out of both that and training with a stomach bug.
He has since recovered sufficiently to be in the starting XI at right-back.
Cengiz Under has been the form player for Roma in recent weeks, contributing four goals and an assist in the last three Serie A games.
There were some doubts as to whether he’d start tonight, as Gregoire Defrel or Gerson would provide more defensive coverage, but he is chosen for his Champions League debut.
Diego Perotti gets the nod ahead of Stephan El Shaarawy on the left, and in fact the Little Pharaoh isn't even on the bench.
The 4-2-3-1 formation remains intact, with Radja Nainggolan in a more advanced role supporting Edin Dzeko.
Shakhtar Donetsk have played only one competitive match since the Winter break and that could affect their fitness levels.
Coach Paulo Fonseca had concerns over Bernard’s shoulder, but he took part in the full training session on Tuesday and is in the starting XI.
Darijo Srna is still suspended after failing a doping test, though he continues to plead his innocence, while midfielder Maksym Malyshev is injured.
Bohdan Butko is picked to play at right-back, while Brazilian midfielder Fred already has a deal to join Manchester City next term.
There is a lot of Brazilian flair in the Shakhtar side, primarily in attack with Taison, Marlos, Bernard and Facundo Ferreyra.
The Ukrainians won all three of their home games in the group stage, beating Napoli, Feyenoord and Manchester City.
Defender Rakitskiy has to be careful, as a yellow card would rule him out of the second leg.
Shakhtar Donetsk: Pyatov; Butko, Kryvtsov, Rakitskiy, Ismaily; Fred, Stepanenko; Marlos, Taison, Bernard; Ferreyra
Shakhtar bench: Shevchenko, Ordets, Dentinho, Kovalenko, Patrick, Petriak, Zubkov
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; De Rossi, Strootman; Cengiz Under, Nainggolan, Perotti; Dzeko
Roma bench: Skorupski, Peres, Juan Jesus, Pellegrini, Schick, Gerson, Defrel
Ref: Collum (SCO)
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