Milan and Lazio will learn their Europa League opponents later today, when the Last 16 draw takes place in Nyon.
The Rossoneri thrashed Ludogorets 4-0 on aggregate, while the Aquile overcame a first leg defeat to Steaua Bucharest with a convincing 5-1 win at the Stadio Olimpico last night.
The draw for the next round takes place at 12.00 UK time in Switzerland today, with no seedings or country protection.
That means the two Serie A sides could, in theory, draw each other for the Last 16.
They will not be joined by Napoli and Atalanta, who were eliminated by RB Leipzig and Borussia Dortmund respectively.
Europa League Last 16 teams:
Zenit St Petersburg
See the latest Serie A predictions and betting tips with Eurotips.co.uk