Bologna unveil a new 3-5-1-1 formation with Blerim Dzemaili supporting Mattia Destro, as Genoa seek a fourth consecutive victory.
It kicks off at 17.00 GMT, follow the build-up and action from this game and Inter-Benevento on the LIVEBLOG.
Both sides are locked together on 30 points going into the Stadio Dall’Ara and there were concerns the match would be called off due to heavy snowfall, but over the last 24 hours rain and then sun melted away the ice.
The hosts are fresh from an important victory over Sassuolo, ending a run of three defeats in a row, but are forced into several changes.
Defender Sebastien De Maio is suspended against his former club, while Rodrigo Palacio is out for three to four weeks with a thigh strain.
Simone Verdi returns, but is only fit enough for the bench, so Roberto Donadoni unveils an all-new 3-5-1-1 formation with Federico Di Francesco and Adam Masina as the wing-backs, Dzemaili in a new more advanced role supporting Destro.
Genoa are on sparkling form and won their last three on the bounce, beating Inter 2-0 at Marassi last week.
Goran Pandev was the star of that show and he leads the way with Diego Laxalt and Andrej Galabinov again.
Miguel Veloso, Giuseppe Rossi, Armando Izzo and Adel Taarabt are still on the treatment table.
This was an ill-tempered affair last term with three red cards, two of them for Genoa in the closing minutes of a 1-0 Grifone victory.
Genoa have won only four of their 42 previous top flight visits to Bologna, drawing 17 and losing 21.
Bologna: Mirante; Romagnoli, Gonzalez, Helander; Di Francesco, Poli, Pulgar, Nagy, Masina; Dzemaili; Destro
Genoa: Perin; Rossettini, Spolli, Zukanovic; Rosi, Bessa, Bertolacci, Hiljemark, Laxalt; Pandev, Galabinov