Lazio and Milan are fighting on three fronts and go full-strength for a place in the Coppa Italia Final, as the tie is on a knife-edge.
It kicks off at 19.45 GMT, follow the build-up and action while giving your views on the LIVEBLOG.
The first leg ended goalless at San Siro on January 31, so the Aquile have home advantage at the Stadio Olimpico, but the Rossoneri can make the most of the away goals rule.
Gennaro Gattuso’s men are fresh from a 2-0 victory in this arena on Sunday evening, when they beat Roma in a big Serie A fixture.
They use the same line-up, including Patrick Cutrone, despite reports Nikola Kalinic would start so the youngster could be fresh for Sunday’s Derby della Madonnina with Inter.
It’s a special match for ex-Lazio midfielder Lucas Biglia, while former Roma defender Alessio Romagnoli confessed this week to being a Biancocelesti supporter.
Milan are unbeaten in 11 competitive games and have set up a Europa League Round of 16 clash with Arsenal.
Lazio are also flying high in third place in Serie A, will meet Dinamo Kiev in Europe and have Capocannoniere Ciro Immobile leading the way.
Simone Inzaghi’s side had gone through a brief rough patch, winless in five official matches, but put that to rest by beating FCSB 5-1 and Sassuolo 3-0.
Luis Alberto returns in place of Felipe Anderson as support for Immobile, with Sergej Milinkovic-Savic hoping to further increase his price-tag.
Luiz Felipe is carrying a knock, so Martin Caceres steps into the back three.
Lazio are aiming to reach the Coppa Italia Final for the second year running, while it’d be Milan’s second in three seasons.
These teams have already met twice in Serie A this season, Lazio winning 4-1 at home and falling 2-1 away on January 28 – just three days before the Coppa Italia first leg draw.
Milan’s last Coppa Italia trip to Lazio was a 4-0 drubbing in the 2003-04 semi-final second leg and they’ve won only one of their last eight visits in all competition, losing four.
The winners will face Juventus in the one-off Final at the Stadio Olimpico in May.
Lazio: Strakosha; Caceres, De Vrij, Radu; Marusic, Parolo, Leiva, Milinkovic-Savic, Lulic; Luis Alberto; Immobile
Lazio bench: Guerrieri, Vargic, Patric, Basta, Bastos, Luiz Felipe, Wallace, Lukaku, Murgia, Nani, Felipe Anderson, Caicedo
Milan: G Donnarumma; Calabria, Bonucci, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Cutrone, Calhanoglu
Milan bench: A Donnarumma, Guarnone, Abate, Gomez, Musacchio, Zapata, Locatelli, Mauri, Montolivo, Borini, Kalinic, Andre Silva
See the latest Serie A predictions and betting tips with Eurotips.co.uk