SPAL are desperate for points to escape the drop zone and host a Bologna side who welcome back Simone Verdi in this local derby.
It kicks off at the Stadio Mazza at 14.00 GMT, although there will be a pitch inspection after heavy rainfall.
The Spallini are in the bottom three, but only one point behind Crotone and three adrift of Sassuolo, while Cagliari and Chievo are still within reach too.
Leonardo Semplici received the backing of the club and has started to turn things around with last week’s 3-2 victory over Crotone.
Pasquale Schiattarella is suspended, with Marco Borriello and Eros Schiavoni injured, so Alberto Paloschi and Mirco Antenucci again lead the way.
Bologna are galvanised by back-to-back wins over Sassuolo and Genoa, helping them to break away from the danger zone.
Coach Roberto Donadoni is still missing Rodrigo Palacio, but has Simone Verdi back in the starting XI for the first time in over a month following his thigh strain.
Mattia Destro seems to have rediscovered his confidence and starts in attack of a 3-5-2 formation, so a more central role than Verdi is accustomed to.
The last time these teams met at the Stadio Mazza was a Serie C1 fixture in 1994-95.
SPAL: Meret; Felipe, Vicari, Cionek; Lazzari, Kurtic, Viviani, Grassi, Mattiello; Paloschi, Antenucci
Bologna: Mirante; De Maio, Gonzalez, Helander; Di Francesco, Dzemaili, Pulgar, Poli, Masina; Destro, Verdi