Juventus are expected to use a fluid formation with Douglas Costa and Paulo Dybala supporting Gonzalo Higuain against Tottenham.
The Champions League Round of 16 concludes this evening at 19.45 GMT after the 2-2 first leg draw in Turin.
Max Allegri is without Mario Mandzukic, Federico Bernardeschi and Juan Cuadrado, while Mattia De Sciglio and Douglas Costa are not 100 per cent fit either.
The latest reports from London suggest Andrea Barzagli could be used at right-back rather than De Sciglio or Stephan Lichtsteiner, providing more defensive coverage down that flank.
Douglas Costa and Dybala can support Higuain, who makes his first appearance since spraining his ankle against Torino.
It's fluid, because at times it could effectively be a 3-5-2 with Douglas Costa and Alex Sandro pushing further up, at others a 4-4-2 and even a 4-3-2-1, depending on possession and approach.
Tottenham have one real doubt for the line-up and that’s between Son Heung-Min and Erik Lamela, with the former Roma star having been chosen for the first leg.
Toby Alderweireld is injured and Serge Aurier suspended, so Kieran Trippier gets his first Champions League start at right-back.
Tottenham: Lloris; Trippier, Sanchez, Vertonghen, Davies; Dier, Dembele; Eriksen, Alli, Son (Lamela); Kane
Juventus: Buffon; Barzagli, Benatia, Chiellini, Alex Sandro; Khedira, Pjanic, Matuidi; Douglas Costa, Dybala; Higuain