Milan are missing Ignazio Abate, Luca Antonelli and Mateo Musacchio for the Europa League meeting with Arsenal.
The first leg of the Round of 16 is on Thursday at 18.00 GMT.
Coach Gennaro Gattuso is still missing long-term absentee Andrea Conti, but added defenders Abate, Antonelli and Musacchio to that list.
Arsenal have left Alexandre Lacazette, Hector Bellerin and Nacho Monreal behind in London.
Milan squad for Arsenal: A Donnarumma, G Donnarumma; Bonucci, Calabria, Rodriguez, Romagnoli, Zapata; Biglia, Bonaventura, Calhanoglu, Locatelli, Kessie, Montolivo; Borini, Cutrone, Kalinic, Andre Silva, Suso
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