Juventus can at least temporarily go top of the table if they beat Udinese and start with Gonzalo Higuain, Paulo Dybala and Douglas Costa.
It kicks off at 14.00 GMT, follow the build-up and action from all today’s Serie A games on the LIVEBLOG.
The Bianconeri are hitting form at the right time, reaching the Coppa Italia Final, beating Tottenham 2-1 at Wembley on Wednesday to qualify for the Champions League quarter-finals and sitting just one point behind Serie A leaders Napoli with a game in hand.
Max Allegri is forced into some changes, as Alex Sandro and Stephan Lichtsteiner are both suspended, with Federico Bernardeschi and Juan Cuadrado long-term injury absentees.
De Sciglio missed the Spurs game, but is back in the starting XI, as Gigi Buffon, Miralem Pjanic and Andrea Barzagli are rested.
Udinese have ground to a halt lately with three consecutive defeats, but this has been no ordinary week for them.
Just hours before their planned Serie A encounter with Fiorentina last Sunday, Viola captain Davide Astori was found dead in the team hotel, having passed away in his sleep aged only 31.
It was a traumatising event for Udinese players too.
Massimo Oddo is trying to get his men focused for this first match back, but has a shortage of options because Danilo and Kevin Lasagna are injured with Jens Stryger-Larsen suspended.
Jakub Jankto, a transfer target for Juve, Milan and Inter, is again moved to a more advanced role to support Maxi Lopez.
Udinese have only beaten Juventus twice since the turn of the decade, but curiously both victories have been in Turin, the last of which coming in January 2011 with Alexis Sanchez on target. Juve have only failed to win three of their last 12 meetings.
Juventus: Szczesny; De Sciglio, Rugani, Chiellini, Asamoah; Khedira, Marchisio, Sturaro; Douglas Costa, Higuain, Dybala
Udinese: Bizzarri; Nuytinck, Angella, Samir; Widmer, Barak, Behrami, Fofana, Ali Adnan; Jankto; Maxi Lopez
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