Roma need to beat Shakhtar Donetsk to reach the Champions League quarter-final, so the pressure is on Edin Dzeko and Cengiz Under.
It kicks off at 19.45 GMT, follow the build-up and action while giving your views on the LIVEBLOG.
The first leg ended 2-1 in Ukraine, as Cengiz Under had given the Giallorossi the lead, but a poor second half performance saw them overturned by Facundo Ferreyra and Fred.
It could’ve been worse if not for the heroics of goalkeeper Alisson Becker and a last-gasp Bruno Peres goal-line clearance.
Dzeko leads the way with support from Under and Diego Perotti, while Daniele De Rossi, Radja Nainggolan and Kevin Strootman take the midfield reins.
Gregoire Defrel and Rick Karsdorp are out injured.
Shakhtar Donetsk are not to be underestimated, because they finished ahead of Napoli in their Champions League group.
It must be noted that they won the home leg 2-1 and lost 3-1 away at the Stadio San Paolo, so tend to struggle on their travels.
They have a Portuguese Coach and many Brazilian players to bring flair, including Marlos, Taison, Bernard, Facundo Ferreyra and Fred.
Ferreyra has scored 16 goals in his last 16 competitive games for Shakhtar.
The visitors are without injured midfielder Maksym Malyschev and defender Serhiy Kryvstov, while Darijo Srna failed a doping test.
These sides have met before in the Champions League and Shakhtar won four out of five encounters, losing 4-0 in 2006.
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; Nainggolan, De Rossi, Strootman; Under, Dzeko, Perotti
Roma bench: Skorupski, Peres, Juan Jesus, Pellegrini, Gerson, El Shaarawy, Schick
Shakhtar Donetsk: Pyatov; Butko, Ordets, Rakitsky, Ismaily; Fred, Stepanenko; Marlos, Taison, Bernard; Facundo Ferreyra
Shakhtar Donetsk bench: Kudryk, Petriak, Khocholava, Dentinho, Patrick, Kovalenko, Zubkov
Ref: Mallenco (ESP)
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