Lazio have to fight back from a 2-2 home draw as they visit Dynamo Kiev, so rely on Felipe Anderson and Ciro Immobile.
It kicks off at 18.00 GMT, follow the build-up and action as it happens from this game and Arsenal-Milan on the LIVEBLOG.
The Aquile have been stuttering in recent weeks, going out of the Coppa Italia semi-final on penalties to Milan and sliding down the Serie A standings after some controversial setbacks.
Lazio have to fight back from a 2-2 home draw as they visit Dynamo Kiev, so rely on Felipe Anderson and Ciro Immobile.
It kicks off at 18.00 GMT, follow the build-up and action as it happens from this game and Arsenal-Milan on the LIVEBLOG.
The Aquile have been stuttering in recent weeks, going out of the Coppa Italia semi-final on penalties to Milan and sliding down the Serie A standings after some controversial setbacks.
Simone Inzaghi even declared he prefers playing in the Europa League because “there is no VAR” in this tournament.
Nonetheless, the first leg did not go as planned, because they were held to a 2-2 draw by Dynamo Kiev and Immobile hit the post deep into stoppages.
Immobile leads the attack again in Ukraine with support from Felipe Anderson, but Sergej Milinkovic-Savic, Martin Caceres and Dusan Basta are out injured.
Luis Alberto is not fully fit either, having skipped training for a couple of days on paternity leave, but still starts with Lucas Leiva and Patric in midfield.
Dynamo Kiev are without suspended Denys Garmash in attack, but Georgi Bushchan, Serhiy Sydorchuk, Vladyslav Kalitvintsev and Dieudonne Mbokani Bezua are still sidelined.
The Kiev club have a poor home record against Italian sides, managing one win, three draws and seven losses.
That included Lazio’s success here in the 1999-2000 Champions League group stage, a game featuring Simone Inzaghi.
Dynamo Kiev: Boyko; Kedziora, Burda, Kadar, Pivaric; Buyalskiy, Shepeliev; Morozyuk, Moraes, Tsygankov; Besedin
Dynamo Kiev bench: Rudko, Khacheridi, Shabanov, Gonzalez, Shaparenko, Alibekov, Mbokani
Lazio: Strakosha; Luiz Felipe, De Vrij, Radu; Patric, Parolo, Leiva, Luis Alberto, Lulic; Felipe Anderson; Immobile
Lazio bench: Guerrieri, Wallace, Bastos, Lukaku, Marusic, Murgia, Nani, Caicedo
Ref: Jesus Gil Manzano (ESP)