Roma aim to keep the momentum going and start Stephan El Shaarawy, but Crotone are desperate for points and fresh from humiliating Sampdoria.
It kicks off at the Stadio Scida at 14.00 GMT.
The Giallorossi have found their confidence, beating Napoli at the San Paolo and Shakhtar Donetsk to book a Champions League quarter-final spot against Barcelona.
Diego Perotti, Gregoire Defrel and Rick Karsdorp haven’t made the trip, while captain Daniele De Rossi is suspended, so Lorenzo Pellegrini, Maxime Gonalons, Gerson and Stephan El Shaarawy are in the starting XI, resting Cengiz Under and Kevin Strootman.
Crotone have a long list of absentees, missing Mariano Izco, Ante Budimir, Marcus Rohden, Stefan Simic and Roma-owned Marco Tumminello.
Coach Walter Zenga is eager to keep the enthusiasm going after they humiliated Sampdoria 4-1 last week, as Marcello Trotta leads the trident attack with Andrea Nalini and former Roma youth product Federico Ricci.
Crotone have faced Roma three times in Serie A and are yet to score their first goal, conceding seven.
Crotone: Cordaz; Faraoni, Ceccherini, Capuano, Martella; Stoian, Mandragora, Benali; Ricci, Trotta, Nalini
Roma: Alisson; Peres, Fazio, Juan Jesus, Kolarov; Nainggolan, Gonalons, Pellegrini; Gerson, Dzeko, El Shaarawy