Lazio must beat troubled Bologna to stay in the top four, so use Felipe Anderson, Luis Alberto, Luis Nani and Ciro Immobile.
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The Aquile risk fatigue after Thursday’s hard-fought 2-0 victory away to Dynamo Kiev, which booked their place in the Europa League quarter-finals.
They will take on RB Salzburg next month, but first have to pick up precious Serie A points after Milan, Inter and Roma all won today.
Coach Simone Inzaghi cannot start Milinkovic-Savic, as he is still not fully fit after missing the Kiev trip, so Luis Alberto takes a deeper role with Felipe Anderson out wide.
The big surprise is Nani supporting hitman Ciro Immobile, as the Portuguese veteran rarely gets a start, but clearly the Biancocelesti feel they need to go out all guns blazing to break down a defensive Bologna.
Senad Lulic, Patric and Stefan Radu are also on the treatment table.
Bologna are in crisis after some poor results and even worse performances, particularly Mattia Destro’s miss of the season.
Andrea Poli and Riccardo Orsolini are injured, but Rodrigo Palacio returns from a lengthy lay-off and is the partner to Simone Verdi.
Federico Di Francesco is somewhat surprisingly dropped, putting Vasilis Torosidis in a wider role to best block the dangerous Lazio wingers.
Lazio: Strakosha; Luiz Felipe, De Vrij, Wallace; Marusic, Parolo, Leiva, Luis Alberto, Felipe Anderson; Nani, Immobile
Bologna: Mirante; De Maio, Helander, Gonzalez; Torosidis, Dzemaili, Pulgar, Donsah, Masina; Verdi, Palacio
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