Alex Sandro and Giorgio Chiellini are expected to miss the match with Milan, as Juventus rest them for Real Madrid and the Champions League.
The first leg of the quarter-final is on Tuesday April 3 in Turin, so their Serie A encounter with the Rossoneri is next Saturday.
Mario Mandzukic was sent home early from international duty with several other Croatia players, so he is likely to start.
It could be in his now customary role on the left of a supporting trident, but we cannot rule out a centre-forward position.
This allows rest for Gonzalo Higuain, who was involved with Argentina’s two friendlies against Italy and Spain.
Chiellini and Alex Sandro both pulled out of international duty and will probably be rested at the weekend in order to be in good shape against Real Madrid.
Miralem Pjanic and Medhi Benatia will certainly start against Milan, because they are suspended for the Real Madrid match.
Federico Bernardeschi should learn over the next few days whether he requires surgery that would effectively end his season.