Inter move Joao Cancelo into a more advanced role with Rafinha and Mauro Icardi, while Atalanta start 19-year-old striker Musa Barrow.
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This is a local Lombardy Derby and a big fixture for the hosts, who must win to climb back into the Europa League spots.
At the same time, Inter have slipped out of the top four and simply have to take advantage of the fact Roma and Lazio are going head-to-head tomorrow night.
Atalanta are forced into numerous chances, as Josip Ilicic and Leonardo Spinazzola are injured with Andrea Petagna suspended.
Andreas Cornelius and Jose Luis Palomino are not 100 per cent fit either, so there is the first Serie A start for 19-year-olf striker Barrow, supported by Papu Gomez and Bryan Cristante.
Inter have Marcelo Brozovic banned, with Matias Vecino on the treatment table.
Luciano Spalletti decides to shake things up by resting Antonio Candreva ahead of the midweek round against Cagliari and moving Cancelo to a more advanced role rather than pick Yann Karamoh.
With Rafinha and Ivan Perisic, he’s supporting centre-forward Mauro Icardi, with Borja Valero in midfield.
Davide Santon gets the nod at right-back.
Atalanta have not managed to keep a clean sheet against Inter in 11 consecutive matches, a streak dating back to March 2012, conceding 25 goals.
Atalanta: Berisha; Toloi, Caldara, Masiello; Hateboer, De Roon, Freuler, Gosens; Cristante; Gomez, Barrow
Inter: Handanovic; D’Ambrosio, Skriniar, Miranda, Santon; Gagliardini, Borja Valero; Cancelo, Rafinha, Perisic; Icardi
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