Lazio are ravaged by injuries, but know a win will secure Champions League football, yet Crotone are also desperate to avoid the drop.
It kicks off at 14.00 UK time (13.00 GMT).
Follow the build-up and action as it happens from all eight Serie A games on the LIVEBLOG.
Lazio are ravaged by injuries, but know a win will secure Champions League football, yet Crotone are also desperate to avoid the drop.
It kicks off at 14.00 UK time (13.00 GMT).
Follow the build-up and action as it happens from all eight Serie A games on the LIVEBLOG.
The Aquile were given a huge boost last night when Inter unexpectedly lost at home to Sassuolo, meaning a victory here would open the gap to five points with only one round remaining.
Roma, Napoli and Juventus have mathematically booked their place in the Champions League for next season and Lazio could follow today.
It’s important they create that buffer now ahead of the final showdown at the Olimpico with Inter next weekend.
However, Crotone are just as motivated, because they are only one point clear of the relegation zone and are on the verge of another great escape.
Ahmad Benali and Ante Budimir are still out injured for the Calabrese club, but Simy is in sparkling form in attack and surprisingly joined by Marco Davide Faraoni in a more advanced role than he is accustomed to.
Simone Inzaghi must do without Capocannoniere Ciro Immobile, their top assist provider Luis Alberto, Marco Parolo, Jordan Lukaku and suspended defender Luiz Felipe.
Felipe Anderson therefore uses his pace in support of Felipe Caicedo with Sergej Milinkovic-Savic and Lucas Leiva in midfield.
These two sides have never shared the spoils in Serie A, Lazio winning both home fixtures and losing 3-1 at the Stadio Scida last season.
That was the final game and allowed the Squali to leapfrog Palermo to safety in their maiden top flight campaign.
Inzaghi’s side are unbeaten in nine Serie A rounds and haven’t reached 10 since January 2013.
Crotone: Cordaz; Sampirisi, Ceccherini, Capuano, Martella; Barberis, Mandragora, Rohden; Faraoni, Simy, Nalini
Lazio: Strakosha; Wallace, De Vrij, Radu; Basta, Murgia, Leiva, Milinkovic-Savic, Lulic; Felipe Anderson; Caicedo
Ref: Mazzoleni