Napoli give Piotr Zielinski and Dries Mertens the starting roles against a Sampdoria side struggling amid injuries in attack.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action as it happens from this game and Roma-Juventus on the LIVEBLOG.
The Partenopei have virtually lost the Scudetto, because Juve are six points ahead with two games to play and have a much better goal difference (as the head-to-head record is identical).
Vlad Chiriches and Adam Ounas are out injured, but Arkadiusz Milik is again snubbed in favour of Mertens, while Piotr Zielinski replaces Marek Hamsik.
Sampdoria are out of the running for a Europa League spot, but want to bow out on a high, as they have an excellent home record.
Fabio Quagliarella is injured and cannot face his former club, joined by Ricky Alvarez in the stands.
Duvan Zapata is also an ex-Napoli man and he has not passed a late fitness test, so Dawid Kownacki starts with Gianluca Caprari.
The Blucerchiati's problems got even worse during the warm-up, as Emiliano Viviano suffered an injury and makes way for Vid Belec in goal.
Sampdoria: Belec; Bereszynski, Ferrari, Andersen, Regini; Linetty, Torreira, Praet; Ramirez; Caprari, Kownacki
Napoli: Reina; Hysaj, Albiol, Koulibaly, Mario Rui; Allan, Jorginho, Zielinski; Callejon, Mertens, Insigne