Juventus need only a point to secure the Scudetto and go all-out attack against a Roma side celebrating the Champions League spot.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action from this game and Sampdoria-Napoli on the LIVEBLOG.
The Bianconeri were already celebrating at the Stadio Olimpico on Wednesday when they beat Milan 4-0 to lift their fourth consecutive Coppa Italia.
They’re back in this arena again and can spark the Serie A title party with a seventh straight title.
Thanks to Inter losing against Sassuolo last night, Roma are already sure of a place in the Champions League next season and can enjoy the evening.
It’s a fine way to end a campaign that saw them reach the semi-final, losing only 7-6 on aggregate to Liverpool.
Juan Cuadrado is suspended, with Giorgio Chiellini and Benedikt Howedes injured, but Mattia De Sciglio returns at right-back with Federico Bernardeschi getting a rare start in attack.
He joins Paulo Dybala and Mario Mandzukic in support of Gonzalo Higuain.
Sami Khedira felt a problem in the warm-up and is replaced in the XI by Blaise Matuidi.
Eusebio Di Francesco has his usual 4-3-3, but misses Bruno Peres, Gregoire Defrel and Rick Karsdorp.
Kostas Manolas and Diego Perotti are back in the squad, but not 100 per cent fit, so Juan Jesus and Lorenzo Pellegrini step in.
Cengiz Under and Stephan El Shaarawy flank Edin Dzeko.
Juventus have won six of their last nine Serie A meetings with Roma, losing two, and in that period kept five clean sheets.
However, the Bianconeri have lost their last two trips to the Olimpico.
Roma: Alisson; Florenzi, Fazio, Juan Jesus, Kolarov; Pellegrini, De Rossi, Nainggolan; Under, Dzeko, El Shaarawy
Juventus: Szczesny; De Sciglio, Barzagli, Rugani, Alex Sandro; Matuidi, Pjanic; Bernardeschi, Dybala, Mandzukic; Higuain
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