Milan have left out Andre Silva and Riccardo Montolivo from the squad to face Real Madrid, as the striker is close to Sevilla.
The pre-season friendly will kick off on Saturday evening in Spain at 20.00 UK time.
Coach Gennaro Gattuso must do without injured Pepe Reina, Ivan Strinic and Ignazio Abate.
However, also absent from the list of players are Andre Silva and Montolivo.
Today director Leonardo confirmed Portugal international Silva was one of those who could leave, along with Carlos Bacca.
Sky Sport Italia and AS now claim that Andre Silva is on the verge of a transfer to Sevilla after just two Serie A goals in his debut season, having paid €38m to get him from FC Porto a year ago.
He could even have a medical over the next 48 hours and it's believed to be a loan deal at €5m with option to buy for another €30m.
The Rossoneri already sold Nikola Kalinic to Atletico Madrid this week.
Meanwhile, veteran midfielder Montolivo left the training ground early today, fuelling reports of an imminent move or even a contract termination.
Milan squad to face Real Madrid: A Donnarumma, G Donnarumma, Plizzari; Bellanova, Calabria, Caldara, Musacchio, Rodriguez, Romagnoli, Simic; Biglia, Bonaventura, Brescianini, Calhanoglu, Halilovic, Kessie, Locatelli, Mauri, Torrasi; Bacca, Borini, Cutrone, Higuain, Suso