Milan welcome back Hakan Calhanoglu with Gonzalo Higuain, while Roma change to 3-4-1-2 with Patrik Schick, Javier Pastore and Steven Nzonzi.
It kicks off at San Siro at 19.30 UK time (18.30 GMT), follow the build-up and action as it happens on the LIVEBLOG.
Both sides had a stuttering week, as Gennaro Gattuso’s Milan fumbled a 2-0 lead away to Napoli only to lose 3-2.
Hakan Calhanoglu was suspended for that match and their Week 1 fixture with Genoa was postponed to October 31 due to the Ponte Morandi tragedy.
Andrea Conti and Ivan Strinic are still out of action with long-term fitness issues, but Lucas Biglia retains his midfield spot with Jack Bonaventura and Franck Kessie.
Gonzalo Higuain is looking for his first competitive goal in a Milan jersey.
Despite reports to the contrary, Mateo Musacchio is again chosen ahead of Mattia Caldara in defence.
Roma clawed back a point in their 3-3 thriller with Atalanta on Monday evening, despite trailing 3-1 on their own turf.
Coach Eusebio Di Francesco completely revamps his side in the wake of that game, moving to three at the back including debutant Ivan Marcano, moving Rick Karsdorp and Aleksandar Kolarov to the role of wing-backs.
Javier Pastore shifts again, from midfield to wide attack and now a trequartista behind Dzeko and Schick.
Alessandro Florenzi picked up an injury in the Atalanta game and is therefore ruled out this evening, though Cengiz Under is dropped to the bench with former Milan man Stephan El Shaarawy.
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Higuain, Calhanoglu
Milan bench: Reina, A Donnarumma, Simic, Abate, Caldara, Borini, Laxalt, Mauri, Bertolacci, Bakayoko, Borini, Halilovic, Castillejo, Cutrone
Roma: Olsen; Fazio, Manolas, Marcano; Karsdorp, De Rossi, Nzonzi, Kolarov; Pastore; Schick, Dzeko
Roma bench: Fuzato, Greco, Luca Pellegrini, Santon, Lorenzo Pellegrini, Cristante, Coric, Zaniolo, Kluivert, El Shaarawy, Under
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