Juventus go three at the back as they host Young Boys without Cristiano Ronaldo, as Federico Bernardeschi, Paulo Dybala and Mario Mandzukic start.
It kicks off in Turin at 17.55 UK time (16.55 GMT), follow the build-up and action as it happens from this game and Roma-Viktoria Plzen on the LIVEBLOG.
Juventus go three at the back as they host Young Boys without Cristiano Ronaldo, as Federico Bernardeschi, Paulo Dybala and Mario Mandzukic start.
It kicks off in Turin at 17.55 UK time (16.55 GMT), follow the build-up and action as it happens from this game and Roma-Viktoria Plzen on the LIVEBLOG.
Cristiano Ronaldo was controversially sent off in the opener against Valencia, resulting in a one-match ban, but he will be available for the two showdowns with his old club Manchester United.
The dismissal didn’t dent their progress, as Juve have won every single game so far this season between Serie A and the Champions League.
With Ronaldo out for the first time, Max Allegri reshuffles his pack with a 3-4-1-2 formation that places Bernardeschi in a more central trequartista role behind strikers Dybala and Mandzukic.
Giorgio Chiellini is rested and Sami Khedira not fully fit, so Juan Cuadrado and Alex Sandro take the wide slots with Medhi Benatia and Andrea Barzagli in defence.
Douglas Costa, Mattia De Sciglio and Leonardo Spinazzola are injured.
Young Boys are the minnows of this Group H in their first Champions League proper and lost their opener 3-0 on home turf to Manchester United, with former Juventus star Paul Pogba bagging a first half brace and then providing the assist for Anthony Martial.
They are forced to do without injured centre-back Gregory Wuthrich, Pedro Teixeira and both right-backs Jordan Lotomba and Kevin Mbabu
It means Thorsten Schick has to move into a deeper position to fill the right-back gap rather than his usual wide midfield role.
Midfielder Djibril Sow starts despite carrying an injury, as Guillaume Hoarau leads the attack, but there is a packed midfield in a defensive 4-5-1 formation.
It is the first time these clubs have ever crossed paths in UEFA competition. Juve have won three of their four previous games against Swiss opposition, losing 2-1 at FC Basel in 2003.
Juventus: Szczesny; Barzagli, Bonucci, Benatia; Cuadrado, Pjanic, Matuidi, Alex Sandro; Bernardeschi; Dybala, Mandzukic
Juventus bench: Perin, Chiellini, Khedira, Kean, Joao Cancelo, Emre Can, Bentancur,
Young Boys: Von Ballmoos; Schick, Camara, Von Bergen, Benito; Fassnacht, Sow, Sanogo, Bertone, Sulejmani; Hoarau
Young Boys bench: Wolfli, Ngamaleu, Assale’, Nsame, Aebischer, Garcia, Lauper
Ref: Karasev (RUS)