Gonzalo Higuain returns to the starting XI as Milan host Olympiacos in the Europa League with Suso and Samu Castillejo.
It kicks off at San Siro at 17.55 UK time (16.55 GMT).
The Rossoneri seem to have turned a corner with their 4-1 victory away to Sassuolo at the weekend, achieved without any first-choice strikers available.
Gennaro Gattuso does have the chance to shake things up now, as Higuain is back from a muscular problem and he scored their only previous Europa League goal this season, in a 1-0 win at Dudelange.
The Argentine scored against Olympiacos last season in the Champions League when playing for Juventus. He has seven goals and two assists in his last 12 Europa League appearances.
Pipita is flanked by Spaniards Suso and Castillejo, while Tiemoue Bakayoko and Pepe Reina step in for Franck Kessie and Gianluigi Donnarumma.
Cristian Zapata makes his season debut in defence, giving Mateo Musacchio a rest, as Mattia Caldara is still injured.
Compared to the Luxembourg trip, Milan keep squad rotation to a minimum against arguably the toughest opponents in the group.
Olympiacos opened their European campaign with a 0-0 draw against Real Betis, but achieved that despite going down to 10 men.
Kostas Tsimkas was sent off and the defender is therefore suspended, with Lazaros Christodoulopoulos and Eladbellaoui injured.
Veteran former Manchester City midfielder Yaya Toure is the star man, while Vasilis Torosidis (Roma and Bologna), Giannis Fetfatzidis (Genoa and Chievo) and Guilherme (Udinese) have history in Italian football.
They are fresh from a 1-0 Superleague defeat to rivals PAOK Salonika.
Milan: Reina; Calabria, Zapata, Romagnoli, Rodriguez; Bakayoko, Biglia, Bonaventura; Suso, Higuain, Castillejo
Milan bench: G Donnarumma, Laxalt, Musacchio, Kessie, Borini, Calhanoglu, Cutrone
Olympiacos: Jose Sa; Torosidis, Roderick, Cisse, Koutris; Natcho, Guilherme; Fetfatzidis, Toure, Leiva; Guerrero
Olympiacos bench: Giannotis, Camara, Fortounis, Androutsos, Ahmed Hassan, Meriah, Podence
Ref: Madden (SCO)
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