Roma start both Luca and Lorenzo Pellegrini with Cengiz Under, Stephan El Shaarawy and Edin Dzeko for their trip to Empoli.
It kicks off at 19.30 UK time (18.30 GMT).
The Giallorossi have rediscovered their confidence since moving to a 4-2-3-1 formation, winning three on the bounce against Frosinone, Lazio and Viktoria Plzen.
Above all, Lorenzo Pellegrini has flourished in a more advanced trequartista role behind lone centre-forward Dzeko.
He is given that position from the start today, flanked by Cengiz Under and Stephan El Shaarawy, with Steven Nzonzi and Daniele De Rossi forming a rugged midfield.
Javier Pastore and Aleksandar Kolarov are out injured, so 19-year-old Luca Pellegrini (no relation to Lorenzo) gets his first Serie A start.
Aurelio Andreazzoli was on the Roma bench for the 2013 Coppa Italia Final defeat to Lazio as caretaker manager and took Empoli to win the Serie B title last season.
Luca Antonelli, Manuel Pasqual and Alejandro Rodriguez are unavailable, but Miha Zajc is the talent pulling the strings behind strikers Francesco Caputo and surprise pick, 20-year-old Algeria international Ismael Bennacer.
Afriyie Acquah returns after a spell on the sidelines.
Roma are unbeaten at the Stadio Castellani since 2007.
Empoli: Terracciano; Di Lorenzo, Silvestre, Maietta, Veseli; Acquah, Capezzi, Krunic; Zajc; Bennacer, Caputo
Roma: Olsen; Florenzi, Manolas, Fazio, Lu Pellegrini; Nzonzi, De Rossi; Under, Lo Pellegrini, El Shaarawy; Dzeko
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