Lazio drop Dusan Basta for today’s Fiorentina clash, while Riza Durmisi and Jordan Lukaku are injured.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
The Aquile are struggling after back-to-back defeats against Roma and Eintracht Frankfurt, in which they conceded seven goals and scored two.
Thursday’s 4-1 Europa League loss in Germany had a knock-on effect, because Durmisi is out for several weeks with a suspected dislocated elbow.
Dusan Basta was sent off in that game and is therefore dropped here, although Joaquin Correa does get the call-up.
Jordan Lukaku is a long-term injury absentee.
Striker Felipe Caicedo needs a fitness test, as he has been suffering from flu symptoms over the last few days.
Lazio squad for Fiorentina: Acerbi, Badelj, Bastos, Berisha, Caceres, Caicedo, Cataldi, Correa, Guerrieri, Immobile, Leiva, Luis Alberto, Luiz Felipe, Lulic, Marusic, Milinkovic-Savic, Murgia, Parolo, Patric, Proto, Radu, Strakosha, Wallace