Genoa striker Krzysztof Piatek aims to match Christian Vieri’s record, while Parma are forced to reshuffle without Gervinho and Roberto Inglese.
It kicks off at 11.30 UK time (10.30 GMT), click here for a match preview.
The Grifone have been utterly reliant on Polish forward Piatek and he has scored eight times in just six Serie A appearances so far.
If he finds the net again today, he’ll become the first since Christian Vieri at Inter in 2002-03 to score in each of the first seven Serie A games of the season.
There’s a fair way to go before he can reach Gabriel Batistuta’s all-time record of 11 for Fiorentina in 1994-95.
Piatek is partnered again by young striker Christian Kouame, with Iuri Medeiros chosen rather than Goran Pandev in support.
Lisandro Lopez is the only injury absentee for Davide Ballardini’s men.
Parma, on the other hand, are in the midst of an injury crisis and the biggest loss is former Arsenal and Roma star Gervinho.
He is joined on the sidelines by Roberto Inglese, Jacopo Dezi, Alberto Grassi, Sierralta and Gianni Munari.
It means Fabio Ceravolo has to lead the trident attack with Antonio Di Gaudio and Luca Siligardi.
Genoa: Radu; Biraschi, Spolli, Criscito; Pedro Pereira, Sandro, Hiljemark, Lazovic; Medeiros; Piatek, Kouame
Parma: Sepe; Iacoponi, Bruno Alves, Gagliolo, Gobbi; Rigoni, Stulac, Barillà; Siligardi, Ceravolo, Di Gaudio