Carlo Ancelotti is embracing squad rotation at Napoli with 10 different line-ups in as many games and 21 players starting.
Their match with Sassuolo kicks off at 17.00 UK time (16.00 GMT).
Napoli were famous last season for not making enough changes under Maurizio Sarri, but Ancelotti has gone in the complete opposite direction.
The line-up against Sassuolo is the 10th different version of the Partenopei in as many games.
Adam Ounas is the biggest surprise, as he becomes the 21st different player to start this season for Napoli between Serie A and the Champions League.