Mauro Icardi and Ivan Perisic lead the attack as Inter step into Camp Nou against Barcelona, but Lionel Messi and Radja Nainggolan miss out.
It kicks off at 20.00 UK time (19.00 GMT).
These two sides are joint top of the Champions League group with a 100 per cent record, although the Nerazzurri twice came back to beat Tottenham Hotspur and PSV Eindhoven.
They’ll need that kind of resilience at the mighty Camp Nou, especially as Radja Nainggolan is out injured, with Roberto Gagliardini and Joao Mario not on the UEFA list due to FFP considerations.
Marcelo Brozovic was carrying a knock going in, but is given the all-clear to start with Matias Vecino.
Joao Miranda gets the nod in defence rather than Stefan de Vrij, while Borja Valero fills in for Nainggolan alongside Ivan Perisic and Antonio Candreva.
Danilo D’Ambrosio returns, as Sime Vrsaljko played in Sunday’s last-gasp 1-0 win over Milan.
That was their seventh consecutive victory in all competition.
Barcelona are forced to do without their iconic leader Messi, who has fractured a bone in his arm and is out for three to four weeks.
Rafinha stands in for ‘La Pulga’ with Luis Suarez and former Inter player Philippe Coutinho, meaning two of the front three are former Inter players.
Suarez didn’t train yesterday because his wife was giving birth to their third child, Lautaro.
Samuel Umtiti and Thomas Vermaelen are also out injured, so Clement Lenglet and Sergi Roberto complete the defence.
Barcelona: Ter Stegen; Sergi Roberto, Piqué, Lenglet, Jordi Alba; Rakitic, Busquets, Arthur; Rafinha, Suarez, Coutinho
Barcelona bench: Cillessen, Chumi, Semedo, Vidal, Dembele, Malcom, Munir
Inter: Handanovic; D'Ambrosio, Skriniar, Miranda, Asamoah; Vecino, Brozovic; Candreva, Borja Valero, Perisic; Icardi
Inter bench: Padelli, De Vrij, Ranocchia, Vrsaljko, Politano, Keita Baldé, Lautaro Martinez
Ref: Hategan (ROU)