Lazio rely on Ciro Immobile and Sergej Milinkovic-Savic in a crucial trip to Rudi Garcia’s Olympique Marseille, a battle for second place.
It kicks off at the Stade Velodrome at 20.00 UK time (19.00 GMT).
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Lazio rely on Ciro Immobile and Sergej Milinkovic-Savic in a crucial trip to Rudi Garcia’s Olympique Marseille, a battle for second place.
It kicks off at the Stade Velodrome at 20.00 UK time (19.00 GMT).
The tournament has not gone as hoped for either of these teams so far this season, as Marseille were the Finalists last term, but risk going out in the group stage.
They were beaten by Eintracht Frankfurt, then held to a draw by Apollon Limassol, leaving them on only one point.
Despite boasting star names like Dimitri Payet, Lucas Ocampos, Florian Thauvin (who is injured), Konstantinos Mitroglu and ex-Roma midfielder Kevin Strootman, they have struggled badly.
Also out of action are Aymen Abdennour and ex-Inter and Napoli defender Rolando.
Former Milan defender Adil Rami and veteran goalkeeper Steve Mandanda are up against Ciro Immobile and Felipe Caicedo in a more heavy-duty Lazio front pairing.
Joaquin Correa and Dusan Basta are suspended following their dismissals in the 4-1 defeat to Eintracht Frankfurt, while Luis Alberto, Milan Badelj, Riza Durmisi and Alessandro Murgia are on the treatment table.
It means Lucas Leiva has to do an extra shift in midfield and is joined by Marco Parolo, as Valon Berisha is not considered ready for his first start.
These sides have met four times before, with Lazio winning home and away in the 1999-00 Champions League, then the 2004-05 Intertoto Cup semi-final saw them draw 1-1 in Rome before a 3-0 loss in France.
Coach Simone Inzaghi had an historic evening against Marseille on March 14, 2000, as he became the first and so far only Italian player to score four goals in a single Champions League match.
He picked up a poker in the 5-1 triumph at the Stadio Olimpico under Coach Sven-Goran Eriksson – and saw a penalty saved too.
Olympique Marseille: Mandanda; Sakai, Rami, Kamara, Amavi; Luiz Gustavo, Strootman; Sanson, Payet, Ocampos; Mitroglou
Marseille bench: Pelè, Radonjic, Njie, Caleta-Car, Sarr, Lopez, Germain
Lazio: Strakosha; Wallace, Acerbi, Radu; Caceres, Milinkovic-Savic, Leiva, Parolo, Lulic; Caicedo, Immobile
Lazio bench: Proto, Bastos, Luiz Felipe, Marusic, Berisha, Cataldi, Rossi
Ref: Manzano (ESP)