Lazio rely on Ciro Immobile and Sergej Milinkovic-Savic against Inter’s Mauro Icardi and surprise starter Joao Mario in a repeat of May’s fourth place grudge match.
It kicks off at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
When these sides met back in May, it was the final game of the Serie A season and a head-to-head decider for fourth place.
Matias Vecino rose to nod in a free kick, completing the comeback for a 3-2 victory that sent Inter into the Champions League.
Now Lazio are out for revenge as well as continuing the duel for the same position this time around.
In fact, a win would take Inter into joint second place with Napoli.
Immobile leads the way with support from Felipe Caicedo rather than Luis Alberto, while Milan Badelj comes in for injured Lucas Leiva.
Inter are forced to do without injured ex-Roma star Radja Nainggolan, but Coach Luciano Spalletti chooses a reshuffle of his 4-2-3-1 formation.
Lautaro Martinez had been expected to step in to the trequartista role with Matteo Politano and Ivan Perisic, supporting centre-forward Icardi.
However, in a genuine shock, Luciano Spalletti has chosen Joao Mario in the starting XI.
The Portugal international has made 47 competitive appearances in an Inter jersey, scoring three goals and providing 12 assists.
However, he hasn’t featured for the Nerazzurri since a 1-1 draw with Fiorentina on January 5.
It’s a big game for Icardi, who has scored five goals in eight league games against Lazio, but only one at the Olimpico.
Matias Vecino plays in midfield, with ex-Lazio men Stefan de Vrij, Keita Balde Diao and Antonio Candreva on the bench.
Inter are unbeaten against Lazio in their last four Serie A meetings, winning three of them, and in three of those games scored three goals.
The Nerazzurri are on a run of five consecutive Serie A wins and three away victories on the trot, their best streak on their travels since 2012.
Lazio: Strakosha; Luiz Felipe, Acerbi, Radu; Marusic, Parolo, Badelj, Milinkovic, Lulic; Caicedo, Immobile
Lazio bench: Proto, Guerrieri, Wallace, Bastos, Caceres, Patric, Lukaku, Murgia, Cataldi, Berisha, Luis Alberto, Correa
Inter: Handanovic; Vrsaljko, Miranda, Skriniar, Asamoah; Vecino, Brozovic; Politano, Joao Mario, Perisic; Icardi
Inter bench: Padelli, Ranocchia, De Vrij, Dalbert, D'Ambrosio, Gagliardini, Lautaro Martinez, Borja Valero, Candreva, Keita