Inter give Lautaro Martinez, Dalbert and Joao Mario a chance to shine, but Genoa rest Krzysztof Piatek in favour of Goran Pandev.
The Nerazzurri have won six Serie A games on the bounce and need another victory to keep up with Napoli, who beat Empoli 5-1 last night.
With the Champions League encounter against Barcelona coming up, Luciano Spalletti rotates his squad to rest players like Mauro Icardi, and Matias Vecino.
Lautaro Martinez steps in, while Joao Mario is given his second consecutive start after he was surprisingly picked for the 3-0 win over Lazio last week.
Roberto Gagliardini and Dalbert also get a chance, but Ivan Perisic and Milan Skriniar do start, despite assumptions they would be rested.
Genoa are forced to do without suspended Domenico Criscito, while Nicolas Spolli, Andrea Favilli and Federico Marchetti are injured.
It’s a return to San Siro for ex-Inter men Daniel Bessa and Goran Pandev.
Krzysztof Piatek is eager to get back on track, having fired blanks for two games, but is rested in favour of Pandev.
It’s a special game for goalkeeper Ionut Radu, who is on loan from Inter and in need of a confidence-booster after his last-gasp error gifted Milan a 2-1 victory in the midweek rescheduled Week 1 game.
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Dalbert; Gagliardini, Brozovic; Politano, Joao Mario, Perisic; Lautaro Martinez
Inter bench: Padelli, Vrsaljko, Vecino, Icardi, Keita, Ranocchia, Nainggolan, Asamoah, Borja Valero, Miranda, Candreva
Genoa: Radu; Biraschi, Romero, Gunter; Pereira, Romulo, Sandro, Bessa, Lazovic; Pandev, Kouame
Genoa bench: Vodisek, Russo, Lisandro Lopez, Piatek, Lapadula, Mazzitelli, Lakicevic, Omeonga, Veloso, Medeiros, Zukanovic, Hiljemark
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/