Roma partner Alessandro Florenzi with Justin Kluivert and Edin Dzeko up top for the trip to CSKA Moscow, where Real Madrid already lost last month.
It kicks off at the Luzhniki Stadium at 17.55 GMT.
You can follow the build-up and action as it happens from this game and Juventus v Manchester United on the LIVEBLOG.
Roma partner Alessandro Florenzi with Justin Kluivert and Edin Dzeko up top for the trip to CSKA Moscow, where Real Madrid already lost last month.
It kicks off at the Luzhniki Stadium at 17.55 GMT.
The Giallorossi are currently joint top of the group with Real Madrid on six points, while CSKA can boast four thanks to a 2-2 draw with Viktoria Plzen and shock victory over the reigning champions.
Eusebio Di Francesco’s men ran riot at the Stadio Olimpico with a 3-0 result, so a win in Moscow would allow them to break away definitively from the chasing pack.
These sides have met five times before, with the Giallorossi winning in the 1991-92 Cup Winners’ Cup and the 2014 Champions League group stage.
That season, Rudi Garcia’s men won 5-1 at home and drew 1-1 in Moscow thanks to a Francesco Totti free kick.
Daniele De Rossi, Luca Pellegrini, Diego Perotti and Rick Karsdorp are still unavailable, so Roma retain the 4-2-3-1 formation with Bryan Cristante getting the nod rather than Nicolo Zaniolo in midfield alongside Steven Nzonzi.
Florenzi is moved to a more advanced role on the right side of that supporting trident, with Lorenzo Pellegrini and Kluivert rather than Cengiz Under or Stephan El Shaarawy.
CSKA Moscow are missing Viktor Vasin, Kristiijan Bistrovic, Konstantin Kuchaev and Aleksandar Makarov, while ex-Palermo striker Abel Hernandez is not fully fit.
Fedor Chalov leads the attack as centre-forward, with support from Arnor Sigurdsson.
CSKA Moscow: Akinfeev; Mario Fernandes, Becao, Magnusson, Nababkin; Oblyakov, Bijol, Akhmetov; Vlasic, Sigurdsson; Chalov
CSKA Moscow bench: Pomazun, Chernov, Efremov, Nishimura, Schennikov, Zhamaletdinov, Khosonov
Roma: Olsen; Santon, Manolas, Fazio, Kolarov; Cristante, Nzonzi; Florenzi, Lo Pellegrini, Kluivert; Dzeko
Roma bench: Mirante, Juan Jesus, Marcano, Zaniolo, Under, El Shaarawy, Schick
Ref: Çakır (TUR)