Inter rely on Lautaro Martinez, Keita Balde Diao and Radja Nainggolan against a revitalised Frosinone and Andrea Pinamonti.
It kicks off at San Siro at 19.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri had won seven Serie A matches in a row before their 4-1 demolition at the hands of Atalanta.
This is their first game back since that upset and the break for international duty, but Luciano Spalletti has to make changes ahead of a decisive Champions League trip to Tottenham Hotspur.
Marcelo Brozovic is suspended, with Sime Vrsaljko and Dalbert injured, while Radja Nainggolan returns from the start after his injury worries.
Roberto Gagliardini and Borja Valero take the midfield reins, while there are rare starts for Lautaro Martinez and Keita Balde Diao.
Frosinone are unbeaten in four rounds and seem to have found their form under Coach Moreno Longo.
Federico Dionisi, Luca Paganini, Emil Hallfredsson and Danilo Soddimo are unavailable, with Camillo Ciano and Cristian Molinaro carrying knocks.
This means Daniel Ciofani is partnered by Pinamonti, the Italy Under-21 international centre-forward who is on loan from Inter.
Inter: Handanovic; D'Ambrosio, De Vrij, Skriniar, Asamoah; Gagliardini, Borja Valero, Politano, Nainggolan; Keita Balde; Lautaro
Frosinone: Sportiello; Zampano, Goldaniga, Ariaudo, Capuano, Beghetto; Chibsah, Crisetig, Cassata; Ciofani, Pinamonti
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