Parma rely on Gervinho, while Sassuolo go for an exciting BBB trident of Domenico Berardi, Khouma Babacar and Kevin-Prince Boateng.
It kicks off at the Stadio Tardini at 11.30 GMT, you can follow all the build-up and action from today’s six Serie A games while giving your views on the LIVEBLOG.
These are arguably the two surprise outfits of the campaign so far, because only one point separates them going in.
Parma went bankrupt in 2015 and became the first Italian side to complete three consecutive promotions.
Leo Stulac returns from suspension, but is still left on the bench in favour of Matteo Scozzarella, while Gervinho leads the attack with Luca Siligardi and Roberto Inglese.
Sassuolo miss Jeremie Boga and Claud Adjapong, but Coach Roberto De Zerbi shakes things up with a new BBB trident attack of Berardi, Babacar and Boateng.
Until now, Boateng has largely been used as a False 9, but is moved to the left flank instead.
There is extra motivation for this showdown, because it is a Reggio-Emilia Derby between two neighbouring clubs.
Parma: Sepe; Iacoponi, Bruno Alves, Bastoni, Gagliolo; Grassi, Scozzarella, Barillà; Siligardi, Inglese, Gervinho
Sassuolo: Consigli; Marlon, Magnani, Ferrari, Rogerio; Duncan, Magnanelli, Bourabia; Berardi, Babacar, Boateng
See the latest Serie A predictions and betting tips with Eurotips.co.uk