Genoa hope Krzysztof Piatek can break his goal drought in the Derby della Lanterna, as Sampdoria look to Fabio Quagliarella for inspiration.
It kicks off at 19.30 GMT at a packed Stadio Luigi Ferraris, known commonly as Marassi for the area of the city where the arena resides.
You can follow all the build-up and action as it happens and give your views on the LIVEBLOG.
Genoa hope Krzysztof Piatek can break his goal drought in the Derby della Lanterna, as Sampdoria look to Fabio Quagliarella for inspiration.
It kicks off at 19.30 GMT at a packed Stadio Luigi Ferraris, known commonly as Marassi for the area of the city where the arena resides.
You can follow all the build-up and action as it happens and give your views on the LIVEBLOG.
This is the first Derby della Lanterna since the tragic collapse of the Ponte Morandi, the bridge that practically everyone in the city has crossed at one time or another.
It crumbled on August 14, leaving 43 dead and hundreds homeless.
This is an opportunity to get back to normality for the port city and that means a passionate, fiery, but ultimately fair derby.
Genoa are under pressure with Ivan Juric risking the sack, but he hopes Capocannoniere Piatek can score his first goal since the tactician took over from Davide Ballardini.
Miguel Veloso and Daniel Bessa take the midfield reins, as Sandro is not 100 per cent fit.
Sampdoria lost three on the bounce going into the break for international duty and must do without suspended Karol Linetty, so Jakub Jankto steps in, while Gaston Ramirez is preferred to Riccardo Saponara.
Veteran Quagliarella is accompanied by Gregoire Defrel.
Genoa: Radu; Biraschi, Romero, Criscito; Romulo, Hiljemark, Veloso, Bessa, Lazovic; Kouame, Piatek
Genoa bench: Marchetti, Vodisek, Gunter, Spolli, Pedro Pereira, Lisandro Lopez, Mazzitelli, Omeonga, Medeiros, Rolon, Lakicevic, Pandev, Lapadula, Favilli, Dalmonte
Sampdoria: Audero; Bereszynski, Tonelli, Andersen, Murru; Praet, Ekdal, Jankto; Ramirez; Defrel, Quagliarella
Sampdoria bench: Belec, Rafael, Sala, Colley, A Ferrari, Tavares, Rolando, Leverbe, Saponara, Vieira, Caprari, Kownacki