Milan have Gonzalo Higuain back against Dudelange, but revamp with Stefan Simic getting his debut in defence and Alen Halilovic for midfield.
It kicks off at San Siro at 17.55 GMT.
It was a single goal from Higuain that decided the only previous meeting between these sides in Luxembourg and Pipita is raring to go after his red card against Juventus and two-match Serie A ban.
That doesn’t apply to the Europa League, so he starts with Patrick Cutrone, while Suso and Gianluigi Donnarumma are rested.
The injury list remains extensive, missing Alessio Romagnoli, Mateo Musacchio, Mattia Caldara, Lucas Biglia and Giacomo Bonaventura, probably not seeing any of them again in 2018.
Samu Castillejo would’ve started, but he is still suspended after his red card against Real Betis.
Gennaro Gattuso therefore gives chances to youth team defender Stefan Simic, who hasn’t played at senior level since a late substitute appearance for Crotone against Inter on February 3.
Summer signing as a free agent Halilovic is also given a very rare appearance, his first start in the Rossoneri jersey.
Dudelange don’t have a single point yet in this debut Europa League season.
It’s very tight at the top, though, as Real Betis are on eight points with Milan and Olympiacos seven.
The Spaniards will be through tonight if they win, or if they draw with Olympiacos and Milan do not beat Dudelange.
Milan: Reina; Calabria, Simic, Zapata, Laxalt; Halilovic, Bakayoko, Bertolacci, Calhanoglu; Cutrone, Higuain
Milan bench: G Donnarumma, Abate, Rodriguez, Mauri, Montolivo, Borini, Suso
Dudelange: Bonnefoi; Schnell, Cruz, Prempeh; Jordanov, Stolz, Kruska, Couturier, Melisse; Sinani; Turpel
Dudelange bench: Esposito, Malget, Pokar, E Agovic, Perez, El Hriti, Kenia
Ref: Bezborodov (RUS)