Lazio desperately need their stars to perform as they host Fabio Quagliarella’s revitalised Sampdoria in a head-to-head for European places.
It kicks off at the Stadio Olimpico at 19.30 GMT.
You can follow the build-up and action as it happens on the LIVEBLOG.
The Aquile have been struggling of late with Sergej Milinkovic-Savic and Luis Alberto shadows of their former selves this season.
Lazio desperately need their stars to perform as they host Fabio Quagliarella’s revitalised Sampdoria in a head-to-head for European places.
It kicks off at the Stadio Olimpico at 19.30 GMT.
You can follow the build-up and action as it happens on the LIVEBLOG.
The Aquile have been struggling of late with Sergej Milinkovic-Savic and Luis Alberto shadows of their former selves this season.
Their poor run of three consecutive draws culminated in a stalemate with bottom of the table Chievo that saw them drop out of the top four.
That also makes this a showdown for European ambitions, as Samp have a firm eye on the Europa League places.
Adam Marusic is the only injury absentee, as Lucas Leiva is fit enough for a spot on the bench.
Felipe Caicedo gets the nod in support of Ciro Immobile, rather than ex-Samp star Joaquin Correa or struggling Luis Alberto, with Patric stepping in for Marusic.
Sampdoria are still without Edgar Barreto and Vasco Regini, but their confidence has been boosted by recent results.
They ended the run of just two points from five rounds with 4-1 thrashing of Bologna.
Gaston Ramirez again gets the nod rather than Riccardo Saponara in the trequartista role behind Gianluca Caprari and veteran Quagliarella, leaving ex-Roma forward Gregoire Defrel on the bench.
The Blucerchiati have a terrible record in this fixture, managing only two draws from 12 Serie A visits since their last victory in January 2005.
Home and away, Lazio have won their last four league meetings with Samp, scoring an average of 3.8 goals per game.
Simone Inzaghi has won all five of his Serie A matches against Marco Giampaolo.
Lazio: Strakosha; Wallace, Acerbi, Radu; Patric, Parolo, Badelj, Milinkovic-Savic, Lulic; Caicedo, Immobile
Sampdoria: Audero; Bereszynski, Colley, Andersen, Murru; Praet, Ekdal, Linetty; Ramirez; Caprari, Quagliarella
Ref: Massa