Cesare Prandelli picks Krzysztof Piatek and Christian Kouame to lead a 3-1-4-2 formation on his Genoa debut against SPAL.
It kicks off at Marassi at 17.00 GMT.
Prandelli becomes Genoa’s third Coach of the campaign after both Davide Ballardini and Ivan Juric were sacked.
Juric’s latest spell – his third at the club – ended with three draws and four defeats.
It is a return to Serie A for ex-Italy CT Prandelli, but he must do without suspended Romulo and Daniel Bessa, while Nicolas Spolli is injured.
Sandro is chosen as a sort of sweeper linking defence to midfield, with Pedro Pereira and Darko Lazovic on the wings.
SPAL are also stuttering at the moment and sit one point behind Genoa in the standings.
Thiago Cionek sits out a ban, so they move to four at the back with Francesco Vicari and Dias Felipe in the middle.
Genoa: Radu; Biraschi, Romero, Criscito; Sandro; Pedro Pereira, Hiljemark, Veloso, Lazovic; Piatek, Kouame
SPAL: Gomis; Bonifazi, Vicari, Felipe, Fares; Lazzari, Schiattarella, Missiroli, Kurtic; Antenucci, Petagna