Milan don’t risk Suso, so Samu Castillejo joins Gonzalo Higuain and Patrick Cutrone in the decisive Europa League trip to Olympiacos.
It kicks off in Athens at 20.00 GMT, you can follow all the action as it happens on the LIVEBLOG.
The Rossoneri are in a strong position to qualify along with Real Betis, as they can even afford to lose, as long as it is not by two clear goals.
That is because they beat Olympiacos 3-1 at San Siro and have the superior head-to-head record.
It’s not easy to be all-attack for the Greek outfit, as the only striker available is Miguel Angel Guerrero, so Kostas Fortounis becomes the centre-forward.
There are some familiar faces, most notably ex-Roma defender Vasilis Torosidis and one-time Inter man Giannis Fetfatzidis, but former Bologna midfielder Lazaros Christodoulopoulos is unavailable.
Also missing out are Yassine Meriah, Dimitris Nikolaou, Nahuel Leiva, Yaya Toure, Ahmed Hassan and Alexandros Voilis.
Milan continue to do without Alessio Romagnoli, Mattia Caldara, Giacomo Bonaventura and Lucas Biglia, while Suso is not risked due to a muscular issue.
Castillejo therefore gets a rare start on the right wing with Hakan Calhanoglu on the left, behind strikers Higuain and Cutrone.
Olympiacos: Jose Sà; Elabdellaoui, Vukovic, Cisse, Koutris; Camara, Guilherme; Fetfatzidis, Fortounis, Podence; Guerrero
Olympiacos bench: Giannoitis, Bouchalakis, Natcho, Vrousai, Tsimikas, Roderick, Torosidis
Milan: Reina; Calabria, Abate, Zapata, Rodriguez; Castillejo, Kessie, Bakayoko, Calhanoglu; Cutrone, Higuain
Milan bench: G Donnarumma, Jose Mauri, Bertolacci, Musacchio, Simic, Halilovic, Laxalt
Ref: Bastien (FRA)