Eusebio Di Francesco could be sacked if he doesn’t beat Cesare Prandelli’s Genoa, so he revamps Roma to a 3-4-3 with Nicolò Zaniolo as False 9.
It kicks off at the Stadio Olimpico at 19.30 GMT.
The Giallorossi are in crisis after sliding down the Serie A standings and, although they qualified for the Champions League Round of 16, they lost the final two games.
There are reports the Coach could be dismissed if he fails to beat struggling Genoa this evening.
Edin Dzeko, Stephan El Shaarawy, Lorenzo Pellegrini and Rick Karsdorp are still out of action, with Daniele De Rossi not fit to start.
Patrik Schick had until now been used, but he is the only available striker and is still dropped to the bench, as DiFra takes some big risks.
He revamps the side from 4-3-3 and 4-2-3-1 to a 3-4-3 formation with trequartista Zaniolo in the False 9 role, flanked by Cengiz Under and Justin Kluivert.
Genoa are under their third tactician of the campaign, after dismissing Davide Ballardini and Ivan Juric.
They made their debut with Prandelli in last week’s 1-1 draw with SPAL, an impressive result considering Domenico Criscito was sent off after just 11 minutes.
Criscito is therefore suspended, with Gianluca Lapadula, Koray Gunter and Luca Mazzitelli injured.
Capocannoniere Krzysztof Piatek leads the way with pacey forward Christian Kouame.
Ervin Zukanovic, a former Roma player, steps in to the defence for Criscito.
Genoa have a famously awful record against Roma, losing each of their last 12 visits to the Capital.
The atmosphere will be tense, as the ultras in the Curva Sud have announced a protest against President James Pallotta. They will stay silent for the first 10 minutes, with no flags.
There were dozens of banners put up all over the city last night with the same message: ‘Pallotta vattene’ – Pallotta leave.
Roma: Olsen; Fazio, Manolas, Juan Jesus; Florenzi, Cristante, Nzonzi, Kolarov; Under, Zaniolo, Kluivert
Roma bench: Fuzato, Mirante, Karsdorp, Luca Pellegrini, Perotti, Schick, Marcano, De Rossi, Santon, Coric, Pastore, Marcucci
Genoa: Radu; Biraschi, Romero, Zukanovic; Romulo, Hiljemark, Sandro, Bessa, Lazovic; Piatek, Kouamé
Genoa bench: Marchetti, Russo, Spolli, Lisandro Lopez, Rolon, Pandev, Dalmonte, Pereira, Favilli, Omeonga, Veloso, Medeiros
Ref: Di Bello
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