Lazio have been drawn Europa League specialists Sevilla in the Round of 32 as Inter get Rapid Vienna and Napoli are handed FC Zurich.
Sevilla won three consecutive Europa Leagues between 2014 and 2016 and are second in La Liga, with only Barcelona above them.
Rapid, for their part, finished runners-up in their group ahead of Rangers and Spartak Moscow, while Zurich only returned to the Swiss top flight last year.
Inter and Napoli dropped into the draw after third-place finishes in the Champions League group, although neither side could not face Lazio due to country restrictions.
The seeded teams are at home in the second legs and the ties kick off across February 12-14, ahead of the return fixtures a week later.
Sevilla will play their home second legs on Wednesday February 20 as opposed to Thursday so they do not play at the same time as city rivals Real Betis, who will be hosting Stade Rennais.
Europa League last-32 draw in full:
Viktoria Plzen v Dinamo Zagreb
Club Brugge v Red Bull Salzburg
Rapid Vienna v Inter
Slavia Prague v Racing Genk
FC Krasnodar v Bayer Leverkusen
FC Zurich v Napoli
Malmo v Chelsea
Shakhtar Donetsk v Eintracht Frankfurt
Celtic v Valencia
Stade Rennais.v Real Betis
Olympiacos v Dynamo Kiev
Lazio v Sevilla
Fenerbahce v Zenit St Petersburg
Sporting CP v Villarreal
BATE Borisov v Arsenal
Galatasaray v Benfica