Lazio are taking no chances against Coppa Italia minnows Novara today, as Felipe Caicedo, Ciro Immobile and Sergej Milinkovic-Savic should start.
The Round of 16 tie kicks off at the Stadio Olimpico at 14.00 GMT.
Novara are a big surprise at this stage of the tournament, as the Serie C outfit eliminated Perugia, Brescia and Pisa to reach the final 16.
They must do without suspended defender Angelo Tartaglia, injured Daniele Cacia and Gianluca Sansone.
Nicolas Schiavi is likely to get the trequartista role supporting Jacopo Manconi and Umberto Eusepi.
Lazio have left out Martin Caceres and Dusan Basta ahead of an expected transfer, while the trio of Danilo Cataldi, Alessandro Rossi and Stefan Radu are all suspended.
Simone Inzaghi does not want to risk an early exit from the Coppa Italia, so is fielding a strong formation.
Caicedo seems to have the upper hand over Joaquin Correa when it comes to supporting Immobile, with Luis Alberto and Milinkovic-Savic in deeper roles.
The winners go on to face either Inter or Benevento in the Quarter-Finals.
Lazio: Strakosha; Bastos, Luiz Felipe, Acerbi; Marusic, Milinkovic-Savic, Badelj, Luis Alberto, Lukaku; Caicedo, Immobile
Novara: Benedettini; Cinaglia, Sbraga, Bove, Visconti; Sciaudone, Ronaldo, Nardi; Schiavi; Manconi, Eusepi