Bologna are expected to start Roberto Soriano and Nicola Sansone in tonight’s Coppa Italia tie, with Cristiano Ronaldo and Moise Kean for Juventus.
The Round of 16 fixture kicks off at the Stadio Dall’Ara at 19.45 GMT.
Pippo Inzaghi’s Bologna must do without injured Federico Santander, Blerim Dzemaili and Adam Nagy, but it gives the ideal opportunity to debut the pair of big January signings.
Midfielder Soriano and forward Sansone arrived on loan from Villarreal, although Soriano had spent the first six months of the season at Torino.
With Santander sidelined, Diego Falcinelli looks to be the favourite ahead of Mattia Destro to take the centre-forward role, with Rodrigo Palacio rested.
Andrea Poli is suspended after he was caught on camera using a blasphemous phrase during Bologna’s 3-0 Coppa Italia victory over Crotone.
Juventus miss Mario Mandzukic, Juan Cuadrado, Joao Cancelo and Andrea Barzagli for this trip.
Cristiano Ronaldo makes his Coppa Italia debut in the trident attack with Paulo Dybala and teenager Kean, who starts as reward for ignoring the many offers he has received in this transfer window.
Emre Can, Daniele Rugani and Leonardo Spinazzola are expected to get rare starts.
The winners go on to face Atalanta or Cagliari in the quarter-final.
Bologna: Skorupski; Calabresi, Danilo, Helander; Mattiello, Donsah, Pulgar, Soriano, Dijks; Sansone, Falcinelli
Juventus: Szczesny; De Sciglio, Bonucci, Rugani, Spinazzola; Emre Can, Bentancur, Matuidi; Dybala, Kean, Ronaldo