Lucas Paquetá makes his Milan debut from the start with Gonzalo Higuain in the Coppa Italia against Fabio Quagliarella’s Sampdoria.
The Round of 16 tie kicks off at Marassi at 17.00 GMT and the winners go on to face either Napoli or Sassuolo in the quarter-final.
With Suso, Lucas Biglia, Jack Bonaventura, Andrea Bertolacci, Mattia Caldara and Ivan Strinic injured, it’s the perfect opportunity to throw new buy Paquetá into the mix.
The 21-year-old arrived from Flamengo at a cost of €35m and takes a midfield spot, with Samu Castillejo and Hakan Calhanoglu flanking Chelsea transfer target Higuain.
Cristian Zapata gets the nod rather than Mateo Musacchio alongside birthday boy Alessio Romagnoli.
Sampdoria rely on Gaston Ramirez in the trequartista role behind strikers Quagliarella and Gianluca Caprari, though Riccardo Saponara is ready to come off the bench against his former club.
Coach Marco Giampaolo does not have Manolo Gabbiadini in the squad, as he only arrived from Southampton yesterday.
Sampdoria: Rafael; Sala, Colley, Tonelli, Murru; Praet, Ekdal, Linetty; Ramirez; Quagliarella, Caprari
Sampdoria bench: Audero, Belec, Andersen, Ferrari, Leverbe, Regini, Tavares, Jankto, Vieira, Saponara, Defrel, Kownacki
Milan: Reina; Abate, Zapata, Romagnoli, Rodriguez; Kessie, Bakayoko, Paquetà; Castillejo, Higuain, Calhanoglu
Milan bench: A Donnarumma, G Donnarumma, Conti, Laxalt, Simic, Strinic, Musacchio, Bertolacci, Mauri, Montolivo, Borini, Cutrone