Fiorentina and Roma use practically full-strength sides for the Coppa Italia quarter-final, with Luis Muriel and Nicolò Zaniolo facing off.
It kicks off at the Stadio Franchi at 17.15 GMT and the winners go on to face Juventus or Atalanta in the semi-finals.
This is probably the only shot at silverware that either club has and they are well aware of that, starting practically their strongest line-ups.
Luis Muriel has been on splendid form since arriving from Sevilla, scoring three goals in two Serie A games, and he leads the trident attack with Federico Chiesa and Kevin Mirallas, resting Giovanni Simeone.
Marco Benassi just received a two-match Serie A ban, so he is first choice in midfield for the Coppa, but Gerson is only on the bench against his former club.
There’s no room even there for Valentin Eysseric, who is looking for a new team in this January window.
Roma want to make the most of Steven Nzonzi and Bryan Cristante, seeing as both will be suspended for this weekend’s Serie A showdown for fourth place with Milan.
Alessandro Florenzi returns at right-back, with Javier Pastore shaking off a lengthy injury lay-off to start in the supporting trident behind Patrik Schick, flanked by Nicolò Zaniolo and Stephan El Shaarawy.
Curiously, Zaniolo started out in the Fiorentina youth academy, moving on to Virtus Entella in 2016, Inter in 2017 and this summer Roma as part of the Radja Nainggolan deal.
Both teams had dramatic matches last week, as Fiorentina edged a 4-3 thriller away to Chievo after going down to 10 men, with Alban Lafont saving a Sergio Pellissier penalty.
Roma fumbled a 3-0 lead with Atalanta to draw 3-3.
This is the 19th Coppa Italia meeting between the clubs, with eight Roma victories, five for Fiorentina and five draws.
The last time they crossed paths in the Coppa, Fiorentina won 2-0 at the Stadio Olimpico in February 2015’s quarter-final.
Fiorentina: Lafont; Milenkovic, Pezzella, Vitor Hugo, Biraghi; Benassi, Veretout, Edimilson Fernandes; Chiesa, Muriel, Mirallas
Roma: Olsen; Florenzi, Fazio, Manolas, Kolarov; Nzonzi, Cristante; Zaniolo, Pastore, El Shaarawy; Schick