Lazio have a big opportunity, but Sergej Milinkovic-Savic is suspended for this trip to local rivals Frosinone, who are feeling confident.
It kicks off at the Stadio Benito Stirpe at 18.00 GMT.
As Roma and Milan played a 1-1 draw last night and Sampdoria lost, it gives Lazio the opportunity to jump into fifth place, only one point shy of the Rossoneri in fourth.
Simone Inzaghi’s men risk fatigue after going to extra time and penalties in the Coppa Italia quarter-final against Inter on Thursday evening.
Milinkovic-Savic is suspended, with Luiz Felipe and Wallace injured, but Francesco Acerbi returns to the defence after his ban.
Felipe Caicedo gets the nod in support of Ciro Immobile, with Luis Alberto and Milan Badelj in a deeper role, Riza Durmisi on the wing.
Frosinone are brimming with confidence after a 4-0 hammering of fellow relegation strugglers Bologna and hope that can be the turning point they need this season.
There’s a long list of absentees, from suspended Francesco Cassata to injured Federico Dionisi, Paolo Ghiglione, Stefan Simic, Nicolò Brighenti and Lorenzo Ariaudo.
Frosinone: Sportiello; Salamon, Capuano, Krajnc; Zampano, Chibsah, Viviani, Valzania, Beghetto; Ciano, Pinamonti
Lazio: Strakosha; Bastos, Acerbi, Radu; Marusic, Parolo, Badelj, Luis Alberto, Durmisi; Caicedo, Immobile